Project Area A: Recently emerged to centre stage – c-di-GMP and the coordination of motility, biofilm formation and differentiation
- The role of the c-di-GMP specific phosphodiesterase NbdA in NO-induced biofilm dispersal in Pseudomonas aeruginosa (Nicole Frankenberg-Dinkel, Funding period 2016-2023)
- Gene regulation in Pseudomonas aeruginosa by
c-di-GMP-dependent alterations in mRNA stability (Susanne Häußler, Funding period 2016-2019) - Unraveling the c-di-GMP modulation network in the opportunistic pathogen Pseudomonas aeruginosa (Susanne Häußler, Funding period 2019-2023)
- Sensory mechanisms and local signaling in
c-di-GMP-mediated signal transduction in E. coli biofilm formation (Regine Hengge, Funding period 2016-2023) - Dynamic basis of the molecular mechanism of nucleotide secondary messenger-sensing riboswitches by NMR spectroscopy (Harald Schwalbe, Funding period 2016-2023)
- Oxygen-dependent control of a diguanylate cyclase lacking canonical sensory and regulatory domains (Sandra Schwarz, Funding period 2016-2019 )
- Regulation of development in Myxococcus xanthus by the second messenger c-di-GMP (Lotte Søgaard-Andersen, Funding period 2016-2019)
- Spatiotemporal control of c-di-GMP signaling in Shewanella via phosphodiesterase PdeB (Kai Thormann, Funding period 2016-2023)
- A light-triggered behavioural switch in cyanobacterial motility (Annegret Wilde, Funding period 2016-2019)
Project Area B: The 'classics' revisited – cAMP, ppGpp and the balance between growth and survival
- Regulation of (p)ppGpp-metabolic activities of RelA, Rel and SpoT (Gert Bange & Daniel Wilson, Funding period 2016-2023)
- Linking second messenger nucleotide signalling with CO2 homeostasis in cyanobacteria: unravelling the SbtB-based network (Karl Forchhammer & Martin Hagemann, Funding period 2019-2023)
- Novel biological functions of ppGpp in Escherichia coli (Franz Narberhaus, Funding period 2016-2023)
- Stringent and heat stress response in Bacillus subtilis (Kürsad Turgay, Funding period 2016-2023)
- Mechanisms of (p)ppGpp action in Staphylococcus aureus (Christiane Wolz, Funding period 2019-2023)
Project Area C: 'Sleeping beauties' just awakening – c-di-AMP, c-AMP-GMP and c-GMP
- Function of c-di-AMP in archaea (Sonja Verena Albers, Funding period 2019-2023)
- Multiplicity and functional diversity of cyclic mononucleotide signaling in Sinorhizobium meliloti (Anke Becker, Funding period 2016-2023)
- Osmolarity-dependent control of cellular c-di-AMP levels and characterization of osmolyte transporters in Listeria monocytogenes (Fabian Commichau & Ralf Ficner, Funding period 2016-2023)
- Molecular basis for the control of K+ uptake via KtrAB and KimA by cyclic di-AMP (Inga Hänelt & Janet Vonck, Funding period 2019-2023)
- Cyclic-diadenosine-monophosphate (c-di-AMP) dependent signaling in Corynebacterium glutamicum: identification of mechanisms of potassium-dependent control of c-di-AMP levels and analysis of regulatory targets of c-di-AMP (Gerd Seibold, Funding period 2016-2019)
- Signal transduction by the essential signal molecule
c-di-AMP in Bacillus subtilis (Jörg Stülke, Funding period 2016-2023) - Cyclic di-AMP metabolism and functions in Streptomyces (Natalia Tschowri, Funding period 2016-2023)
- Structural biochemistry of c-di-AMP degrading enzymes and their regulation (Gregor Witte, Funding period 2016-2019)
Project Area Z: LC-MS analysis of bacterial nucleotide second messangers and chemical proteomics
Associate SPP 1879 Members
- Erhard Bremer (Funding period 2019-2023)
- Gen Enomoto (Funding period 2019-2023)
- Urs Jenal (Funding period 2016-2023)
- Kirsten Jung (Funding period 2016-2023)
- Jeanine Rismondo (Funding period 2019-2023)
- Karin Schnetz (Funding period 2019-2023)
- Sandra Schwarz (Funding period 2019-2023)
- Gerd Seibold (Funding period 2019-2023)
- Victor Sourjik (Funding period 2016-2023)
- Lotte Søgaard-Andersen (Funding period 2019-2023)
- Gottfried Unden (Funding period 2016-2023)
- Annegret Wilde (Funding period 2019-2023)
- Gregor Witte (Funding period 2019-2023)