Research Project

Signal transduction by the essential signal molecule
c-di-AMP in Bacillus subtilis

Bacteria use specific signaling nucleotides as second messengers to adapt their cellular activities to changing environmental conditions. Among all known second messengers, cyclic di-AMP is unique as it is essential in the Gram-positive model organism Bacillus subtilis and in related pathogenic bacteria. Several protein and RNA targets for c-di-AMP have been identified. We have demonstrated that the control of potassium homeostasis is the essential function of c-di-AMP.

In this project, we want to unravel the mechanistic details of c-di-AMP action as well as the so far unknown functions of the target proteins that are not directly involved in potassium homeostasis.

Principle Investigators

Prof Dr. Jörg Stülke
» jstuelk@gwdg.de

Co-workers

Larissa Krüger (Funding period 2019-2022)
» larissa.krueger@uni-goettingen.de

Rica Bremenkamp (Funding period 2019-2022)
» rica.bremenkamp@uni-goettingen.de

Jan Gundlach (Funding period 2016-2019)
» jgundla@gwdg.de

Martin Weiß (Funding period 2016-2019)
» mweiss1@gwdg.de