Research Project

Signal transduction by the essential signal molecule
c-di-AMP in Bacillus subtilis

Bacteria use specific signaling nucleotides as second messengers to adapt their cellular activities to changing environmental conditions. Among all known second messengers, cyclic di-AMP is unique as it is essential in the Gram-positive model organism Bacillus subtilis and in related pathogenic bacteria. Several protein and RNA targets for c-di-AMP have been identified. We have demonstrated that the control of potassium homeostasis is the essential function of c-di-AMP.

In this project, we want to unravel the mechanistic details of c-di-AMP action as well as the so far unknown functions of the target proteins that are not directly involved in potassium homeostasis.

Principle Investigators

Prof Dr. Jörg Stülke


Larissa Krüger (Funding period 2019-2022)

Rica Bremenkamp (Funding period 2019-2022)

Jan Gundlach (Funding period 2016-2019)

Martin Weiß (Funding period 2016-2019)