2018

Bedrunka, P.,  Olbrisch, F.,  Rüger, M.,  Zehner, S., and N. Frankenberg-Dinkel (2018) Nitric oxide controls c-di-GMP turnover in Dinoroseobacter shibae. Microbiology. Sep 17.
doi: 10.1099/mic.0.000714. [Epub ahead of print]» PubMed 

Commichau, F.M., Heidemann, J.L., Ficner, R., and J. Stülke (2018) Making and breaking of an essential poison: the cyclases and phosphodiesterases that produce and degrade the essential second messenger cyclic di-AMP in bacteria. J Bacteriol. Sep 17. pii: JB.00462-18. doi: 10.1128/JB.00462-18. [Epub ahead of print] » PubMed 

Quintana, I., Espariz, M., Villar, S., Gonzalez, F. B., Pacini, F., Cabrera, G., Bontempi, I., Procheto, E., Stülke, J., Perez, A. R., Marcipar, I., Blancato, V., and C. Magni (2018) Genetic engineering of Lactococcus lactis co-producing antigen and the mucosal adjuvant 3′ 5′- cyclic di adenosine monophosphate (c-di-AMP) as a design strategy to develop a mucosal vaccine prototype. Front. Microbiol. 9:2100, Sep 4.
doi: 10.3389/fmicb.2018.02100 https://doi.org/10.3389/fmicb.2018.02100

Beckert, B., Turk, M., Czech, A., Berninghausen, O., Beckmann, R., Ignatova, Z., Plitzko, J.M., and D.N. Wilson (2018) Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1. Nat Microbiol Sep 3. doi: 10.1038/s41564-018-0237-0. [Epub ahead of print]» PubMed 

Klauck, G., Serra, D.O., Possling, A., and R. Hengge (2018) Spatial organization of different sigma factor activities and c-di-GMP signalling within the three-dimensional landscape of a bacterial biofilm. Open Biol. Aug 8(8). pii: 180066. doi: 10.1098/rsob.180066» PubMed 

Keller, H., Weickhmann, A.K., Bock, T., and J. Wohnert (2018) Adenine protonation enables cyclic-di-GMP binding to cyclic-GAMP sensing riboswitches. RNA. Jul 13. pii: rna.067470.118. doi: 10.1261/rna.067470.118[Epub ahead of print]. » PubMed 

Gratani, F.L., Horvatek, P., Geiger, T., Borisova, M., Mayer, C., Grin, I., Wagner, S., Steinchen, W., Bange, G., Velic, A., Maček, B., and C. Wolz (2018)
Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureusPLoS Genet. Jul 9;14(7):e1007514. doi: 10.1371/journal.pgen.1007514. eCollection 2018 Jul» PubMed 

Commichau, F.M., and J. Stülke (2018) Coping with an essential poison: a genetic suppressor analysis corroborates a key function of c-di-AMP in controlling potassium ion homeostasis in Gram-positive bacteria. J Bacteriol. May 24;200(12). pii: e00166-18. doi: 10.1128/JB.00166-18. Print 2018 Jun 15» PubMed

Herbst, S., Lorkowski, M., Sarenko, O., Nguyen, T.K.L., Jaenicke, T., and R. Hengge (2018)
Transmembrane redox control and proteolysis of PdeC, a novel type of c-di-GMP
phosphodiesterase. EMBO J. Apr 13;37(8). pii: e97825. doi: 10.15252/embj.201797825. Epub 2018 Mar 7. » PubMed 

Thongsomboon, W., Serra, D.O., Possling, A., Hadjineophytou, C.Hengge*, R., and
L. Cegelski* 
(2018) Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose. Science. Jan 19;359(6373):334-338. doi: 10.1126/science.aao4096. » PubMed 
Highlighted in:
1. Perspectives Section of the Science Journal: Galperin, M. and Shalaeva, D.: A bacterial coat that is not pure cotton. Science 2018 Jan 19;359(6373):276-277. doi: 10.1126/science.aar5253» Read more
2. Science News: The secret to icky, sticky bacterial biofilms lies in the microbes’ cellulose. » Read more
3. Nature highlight: How bacteria make their fortresses. » Read more
4. Chemical & Engineering News: Bacteria make modified cellulose. » Read more
5. Phys.org News: Bacterial biofilm cellulose found to differ from plant cellulose. » Read more
6. Nature Microbiology: Do Gram-negatives produce cellulose or not? » Read more
7. F1000Prime by G. Nester, 12 February 2018. doi: 10.3410/f.732501572.793542371.
8. 
F1000Prime by C. Whitfield, 16 February 2018. doi: 10.3410/f.732501572.793542459.

Commichau, F.M., Gibhardt, J., Halbedel, S., Gundlach, J., and J. Stülke (2018) A Delicate Connection: c-di-AMP Affects Cell Integrity by Controlling Osmolyte Transport. Trends Microbiol. Mar;26(3):175-185. doi: 10.1016/j.tim.2017.09.003. Epub 2017 Sep 28.
» PubMed
Journal cover March 2018
Highlighted by Faculty of 1000:
Waters, C. : In F1000Prime, 09 October 2017. doi: 10.3410/f.731603148.793537473. 

Gundlach, J., Commichau, F.M., and J. Stülke (2018) Of ions and messengers: an intricate link between potassium, glutamate, and cyclic di-AMP. Curr Genet. Feb;64(1):191-195. doi: 10.1007/s00294-017-0734-3. Epub 2017 Aug 20. » PubMed

2017

Drexler, D.J., Müller, M., Rojas-Cordova, C.A., Bandera, A.M., and G. Witte (2017) Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritimaStructure. Oct 24. pii: S0969-2126(17)30329-5. doi: 10.1016/j.str.2017.10.001. Epub 2017 Oct 26. » PubMed

Sarenko, O., Klauck, G., Wilke, F.M., Pfiffer, V., Richter,A.M., Herbst, S., Kaever, V., and R. Hengge (2017) More than enzymes that make and break c-di-GMP – Local signaling in the interactome of GGDEF/EAL domain proteins of Escherichia coli. mBio. Oct 10;8(5). pii: e01639-17. doi: 10.1128/mBio.01639-17. » PubMed
Highlighted by Faculty of 1000:
1. Sondermann, H. : In F1000Prime, 19 October 2017. doi: 10.3410/f.731966577.793537737;
2. Galperin, M. : In F1000Prime, 20 October 2017. doi:10.3410/f. 731966577.793537754.

Bähre, H., and V. Kaever (2017) Identification and Quantification of Cyclic Di-Guanosine
Monophosphate and Its LinearMetabolites by Reversed-Phase LC-MS/MS. In: Sauer K. (eds)
c-di-GMP Signaling. Methods in Molecular Biology, vol 1657. Humana Press, New York, NY, 1657:45-58. doi: 10.1007/978-1-4939-7240-1_5. » PubMed

Serra, D.O., and R. Hengge (2017) Experimental detection and visualization of the extracellular matrix in macrocolony biofilms. In: Sauer K. (eds) c-di-GMP Signaling. Methods in Molecular Biology, vol 1657. Humana Press, New York, N.Y., 1657:133-145. doi: 10.1007/978-1-4939-7240-1_11. » PubMed

Angerer, V., Essen, L.O., and A. Wilde (2017) Analysis of c-di-GMP levels synthesized by a photoreceptor protein in response to different light qualities using an in vitro enzymatic assay. In: Sauer K. (eds) c-di-GMP Signaling. Methods in Molecular Biology, vol 1657. Humana Press, New York, N.Y., 1657:187-204. doi: 10.1007/978-1-4939-7240-1_15. » PubMed

Kampf, J., Gundlach, J., Herzberg, C., Treffon, K.,  and J. Stülke (2017) Identification of c-di-AMP-binding proteins using magnetic beads. In: Sauer K. (eds) c-di-GMP Signaling. Methods in Molecular Biology, vol 1657. Humana Press, New York, N.Y., 1657:347-359. doi: 10.1007/978-1-4939-7240-1_27» PubMed

Beckert¶, B., Abdelshahid¶, M., Schäfer, H., Steinchen, W., Arenz, S., Berninghausen, O., Beckmann, R., Bange*, G., Turgay*, K., and D.N. Wilson* (2017) Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization. EMBO J. Jul 14;36(14):2061-2072. doi: 10.15252/embj.201696189. Epub 2017 May 3. » PubMed
Highlighted in the News & Views section of the EMBO Journal:
Gonzalez, R.L. Jr. : Survivor: Ribosome Edition. EMBO J. 2017 Jul 14;36(14):1996-1998. doi: 10.15252/embj.201797518. » PubMed

Blötz, C., Treffon, K., Kaever, V., Schwede, F., Hammer, E., and J. Stülke (2017) Identification of the components involved in cyclic di-AMP signaling in Mycoplasma pneumoniae. Front. Microbiol. Jul 13;8:1328. doi: 10.3389/fmicb.2017.01328eCollection 2017. » PubMed

Gundlach, J., Herzberg, C., Hertel, D., Thürmer, A., Daniel, R., Link, H., and J. Stülke (2017) Adaptation of Bacillus subtilis to life at extreme potassium limitation. mBio. Jul 5;8(4). pii: e00861-17. doi: 10.1128/mBio.00861-17» PubMed
Highlighted by Faculty of 1000:
Clausen, T. and Suskiewicz, M. : In F1000Prime, 06 October 2017. doi: 10.3410/f.727781851.793537409.

Angerer, V., Schwenk, P., Wallner, T., Kaever, V., Hiltbrunner, A., and A. Wilde (2017) The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2. Microbiology. Jun;163(6):920-930. doi: 10.1099/mic.0.000475. Epub 2017 Jun 21. » PubMed

Schumacher, MA., Zeng, W., Findlay, K.C., Buttner, M.J., Brennan, R.G., and N. Tschowri (2017) The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. Nucleic Acids Res. Jun 20;45(11):6923-6933. doi: 10.1093/nar/gkx287. » PubMed

Schuergers, N., Mullineaux, C.W., and Wilde, A. (2017) Cyanobacteria in motion. Curr. Opin. Plant Biol. Jun;37:109-115. doi: 10.1016/j.pbi.2017.03.018Epub 2017 May 1. » PubMed

Gundlach, J., Herzberg, C., Kaever, V., Gunka, K., Hoffmann, T., Weiß, M., Gibhardt, J., Thürmer, A., Hertel, D., Daniel, R., Bremer, E., Commichau, F.M., and J. Stülke (2017) Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis. Sci. Signal. Apr 18;10(475). pii: eaal3011. doi: 10.1126/scisignal.aal3011.
» PubMed

2016

Arenz, S., Abdelshahid, M., Sohmen, D., Payoe, R., Starosta, A.L., Berninghausen, O., Hauryliuk, V., Beckmann, R., and D.N. Wilson (2016) The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis. Nucleic Acids Res. 44(13):6471-81. doi: 10.1093/nar/gkw470. Epub 2016 May 25. » PubMed

Krol, E., Klaner, C., Gnau, P., Kaever, V., Essen, LO., and A. Becker (2016) Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti. Microbiology 162(10):1840-1856. doi: 10.1099/mic.0.000356. Epub 2016 Aug 16. » PubMed