2023
Fuss, M. F., Wieferig, J. P., Corey, R. A., Hellmich, Y., Tascón, I., Sousa, J. S., Stansfeld, P. J., Vonck, J., and Hänelt, I. (2023) Cyclic di-AMP traps proton-coupled K+ transporters of the KUP family in an inward-occluded conformation. Nat Commun., 14(1), 3683. https://doi.org/10.1038/s41467-023-38944-1
Hengge R. (2023) The symbolic power of nucleotide second messengers – or how prokaryotes link sensing and responding to their outside world. microLife, 4, uqad036. https://doi.org/10.1093/femsml/uqad036
Brückner, S., Müller, F., Schadowski, L., Kalle, T., Weber, S., Marino, E. C., Kutscher, B., Möller, A.-M., Adler, S., Begerow, D., Steinchen, W., Bange, G., & Narberhaus, F. (2023) (p)ppGpp and moonlighting RNases influence the first step of lipopolysaccharide biosynthesis in Escherichia coli. microLife 4, uqad031, https://doi.org/10.1093/femsml/uqad031
Scherhag, A., Räschle, M, Unbehend, N., Venn, B., Glueck, D., Mühlhaus, T., Keller, S., Pérez Pagallo, E., Zehner, S., & Frankenberg-Dinkel, N. (2023) Characterization of a soluble library of the Pseudomonas aeruginosa PAO1 membrane proteome with emphasis on c-di-GMP turnover enzymes. microLife, 4, uqad028, https://doi.org/10.1093/femsml/uqad028
van der Does, C., Braun, F., Ren, H., & Albers, S. V. (2023) Putative nucleotide-based second messengers in archaea. microLife, 4, uqad027. https://doi.org/10.1093/femsml/uqad027
Junkermeier, E. H., & Hengge, R. (2023) Local signaling enhances output specificity of bacterial c-di-GMP signaling networks. microLife, 4, uqad026. https://doi.org/10.1093/femsml/uqad026
Krol, E., Werel, L., Essen, L. O., & Becker, A. (2023). Structural and functional diversity of bacterial cyclic nucleotide perception by CRP proteins. microLife, 4, uqad024. https://doi.org/10.1093/femsml/uqad024
Neumann, P., Kloskowski, P., & Ficner, R. (2023) Computer-aided design of a cyclic di-AMP synthesizing enzyme CdaA inhibitor, microLife 4, uqad021, https://doi.org/10.1093/femsml/uqad021
Bhowmick, S., Shenouda, M. L., & Tschowri, N. (2023) Osmotic stress responses and the biology of the second messenger c-di-AMP in Streptomyces. microLife, 4, uqad020. https://doi.org/10.1093/femsml/uqad020
Enomoto, G., Wallner, T., & Wilde, A. (2023) Control of light-dependent behaviour in cyanobacteria by the second messenger cyclic di-GMP. microLife, 4, uqad019. https://doi.org/10.1093/femsml/uqad019
Driller, K., Cornejo, F. A., & Turgay, K. (2023) (p)ppGpp – an important player during heat shock response. microLife, 4, uqad017. https://doi.org/10.1093/femsml/uqad017
Zegarra, V., Mais, C. N., Freitag, J., & Bange, G. (2023) The mysterious diadenosine tetraphosphate (AP4A). microLife, 4, uqad016. https://doi.org/10.1093/femsml/uqad016
Hengge, R., Pruteanu, M., Stülke, J., Tschowri, N., & Turgay, K. (2023) Recent advances and perspectives in nucleotide second messenger signaling in bacteria. microLife, 4, uqad015. https://doi.org/10.1093/femsml/uqad015
Kreiling, V., & Thormann, K. M. (2023). Polarity of c-di-GMP synthesis and degradation. microLife, 4, uqad014. https://doi.org/10.1093/femsml/uqad014
Salzer, A., & Wolz, C. (2023) Role of (p)ppGpp in antibiotic resistance, tolerance, persistence and survival in Firmicutes. microLife, 4, uqad009. https://doi.org/10.1093/femsml/uqad009
Mantovani, O., Haffner, M., Selim, K. A., Hagemann, M., & Forchhammer, K. (2023) Roles of second messengers in the regulation of cyanobacterial physiology: the carbon-concentrating mechanism and beyond. microLife, 4, uqad008. https://doi.org/10.1093/femsml/uqad008
Schwedt, I., Wang, M., Gibhardt, J., & Commichau, F. M. (2023) Cyclic di-AMP, a multifaceted regulator of central metabolism and osmolyte homeostasis in Listeria monocytogenes. microLife, 4, uqad005. https://doi.org/10.1093/femsml/uqad005
Walsh, D., Salzer, A., Wolz, C., Aylott, J., & Hardie, K. R. (2023) The biocide triclosan induces (p)ppGpp dependent antibiotic tolerance and alters SarA dependent biofilm structures in Staphylococcus aureus. bioRxiv 2023.02.01.525840;
Selim, K. A., Haffner, M., Mantovani, O., Albrecht, R., Zhu, H., Hagemann, M., Forchhammer, K., & Hartmann, M. D. (2023) Carbon signaling protein SbtB possesses atypical redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA. Proc Natl Acad Sci U S A, 120(8), e2205882120. doi:10.1073/pnas.2205882120
Werel, L., Farmani, N., Krol, E., Serrania, J., Essen, L. O., & Becker, A. (2023) Structural Basis of Dual Specificity of Sinorhizobium meliloti Clr, a cAMP and cGMP Receptor Protein. mBio, 14(2), e0302822. https://doi.org/10.1128/mbio.03028-22
Möller, A. M., Brückner, S., Tilg, L. J., Kutscher, B., Nowaczyk, M. M., & Narberhaus, F. (2023) LapB (YciM) orchestrates protein-protein interactions at the interface of lipopolysaccharide and phospholipid biosynthesis. Mol Microbiol. , 119(1), 29–43. https://doi.org/10.1111/mmi.15005
2022
Meißner, J., Schramm, T., Hoßbach, B., Stark, K., Link, H., & Stülke, J. (2022) How To Deal with Toxic Amino Acids: the Bipartite AzlCD Complex Exports Histidine in Bacillus subtilis. J. Bacteriol. 204: e00353-22. https://doi.org/10.1128/jb.00353-22
Wendel, B. M., Pi, H., Krüger, L., Herzberg, C., Stülke, J., & Helmann, J. D. (2022) A Central Role for Magnesium Homeostasis during Adaptation to Osmotic Stress. mBio, 13(1): e0009222. https://doi.org/10.1128/mbio.00092-22
Schumacher†*, M. A., Wörmann†, M. E., Henderson, M., Salinas, R., Latoscha, A., Al-Bassam, M. M., Singh, K. S., Barclay, E., Gunka, K., & Tschowri*, N. (2022) Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP. († these authors contributed equally, * corresponding authors)
Giammarinaro†, P.I., Young†, M.K.M., Steinchen, W., Mais, C.N., Hochberg, G., Yang, J., Stevenson, D.M., Amador-Noguez, D., Paulus, A., Wang*, J.D., and G. Bange* G (2022) Diadenosine tetraphosphate regulates biosynthesis of GTP in Bacillus subtilis. Nat Microbiol. Aug 11. doi: 10.1038/s41564-022-01193-x. Online ahead of print. († these authors contributed equally, * corresponding authors)
Landgraf, T., Völklein, A. E., Fürtig, B., and Schwalbe, H. (2022). The cotranscriptional folding landscape for two cyclic di-nucleotide-sensing riboswitches with highly homologous aptamer domains acting either as ON- or OFF-switches. Nucleic Acids res. Jul 8;50(12):6639-6655. https://doi.org/10.1093/nar/gkac514
Heidemann†, J.L., Neumann†, P., Krüger, L., Wicke, D., Vinhoven, L., Linden, A., Dickmanns, A., Stülke, J., Urlaub, H., and R. Ficner (2022) Structural basis for c-di-AMP-dependent regulation of the bacterial stringent response by receptor protein DarB. Journal of Biological Chemistry. Available online 15 June 2022, 102144. († these authors contributed equally to this work) doi: https://doi.org/10.1016/j.jbc.2022.102144.
Nakane, D., Enomoto, G., Bähre, H., Hirose, Y., Wilde, A., & Nishizaka, T. (2022) Thermosynechococcus switches the direction of phototaxis by a c-di-GMP-dependent process with high spatial resolution. eLife, 11, e73405. https://doi.org/10.7554/eLife.73405
Wang, M., Wamp, S., Gibhardt, J., Holland, G., Schwedt, I., Schmidtke, K.U., Scheibner, K., Halbedel, S., and F.M. Commichau (2022) Adaptation of Listeria monocytogenes to perturbation of c-di-AMP metabolism underpins its role in osmoadaptation and identifies a fosfomycin uptake system. Environ Microbiol. Jun 10. doi: 10.1111/1462-2920.16084. Online ahead of print.
Mantovani, O., Reimann, V., Haffner, M., Herrmann, F.P., Selim, K.A., Forchhammer, K., Hess, W.R., and M. Hagemann (2022) The impact of the cyanobacterial carbon-regulator protein SbtB and of the second messengers cAMP and c-di-AMP on CO2-dependent gene expression. New Phytol. Jun;234(5):1801-1816. doi: 10.1111/nph.18094. Epub 2022 Apr 9.
Selim,* K.A, Haffner, M., Albrecht, R., Hongbo Zhu, H., Forchhammer, K., and M.D. Hartmann* (2022) Carbon signaling protein SbtB possesses redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA. bioRxiv preprint, version posted May 18. (* corresponding authors) https://doi.org/10.1101/2022.05.18.492403
Kuzmich, S., Blumenkamp, P., Meier, D., Szadkowski, D., Goesmann, A., Becker, A., and L. Søgaard-Andersen (2022) CRP-like transcriptional regulator MrpC curbs c-di-GMP and 3′,3′-cGAMP nucleotide levels during development in Myxococcus xanthus.
mBio. Feb 15;13(1):e0004422. doi: 10.1128/mbio.00044-22. Online ahead of print.
Krüger, L., Herzberg, C., Wicke, D., Scholz, P., Schmitt, K., Turdiev, A., Lee, V.T., Ischebeck, T., and J. Stülke (2022) Sustained control of pyruvate carboxylase by the essential second messenger cyclic di-AMP in Bacillus subtilis. mBio. Feb 8;e0360221. doi: 10.1128/mbio.03602-21. Online ahead of print.
Halte†, M., Wörmann†, M.E., Bogisch, M., Erhardt, M., and N. Tschowri (2022) BldD-based bimolecular fluorescence complementation for in vivo detection of the second messenger cyclic di-GMP. Mol Microbiol. Mar;117(3):705-713. doi: 10.1111/mmi.14876. Epub 2022 Jan 10.
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2021
Junkermeier, E.H., and R. Hengge (2021) A novel locally c-di-GMP-controlled exopolysaccharide synthase required for bacteriophage N4 infection of Escherichia coli.
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Selim†*, K.A, Haffner†, M., Burkhardt, M., Mantovani, O., Neumann, N., Albrecht, R., Seifert, R., Krüger, L., Stülke, J., Hartmann, M.D., Hagemann, M., and K. Forchhammer* (2021) Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB. Sci. Adv. Dec 10;7(50):eabk0568.
doi: 10.1126/sciadv.abk0568. Epub 2021 Dec 8.(† these authors shared co-first authorship,
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Braun, F., Recalde, A., Bähre, H., Roland Seifert. R., and S.V. Albers (2021) Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius. Front. Microbiol. Nov 22;12:779012.
doi: 10.3389/fmicb.2021.779012. eCollection 2021.
Kuzmich, S., Blumenkamp, P., Meier, D., Goesmann, A., Becker, A., and L. Søgaard-Andersen (2021) The CRP-like transcriptional regulator MrpC curbs c-di-GMP and 3’, 3’ cGAMP nucleotide levels during development in Myxococcus xanthus. bioRxiv preprint, version posted October 14. doi: https://doi.org/10.1101/2021.10.01.464357.
Stautz, J., Hellmich, Y., Fuss, M. F., Silberberg, J. M., Devlin, J. R., Stockbridge, R. B., and Hänelt, I. (2021) Molecular Mechanisms for Bacterial Potassium Homeostasis. J Mol Biol., 433(16), 166968. https://doi.org/10.1016/j.jmb.2021.166968 » PubMed
Serra, D.O., and R., Hengge (2021) Bacterial Multicellularity: The biology of Escherichia coli building large-scale biofilm communities. Annu. Rev. Microbiol. Oct 8;75:269-290. doi: 10.1146/annurev-micro-031921-055801. Epub 2021 Aug 3. » PubMed
Junkermeier, E.H., and R. Hengge (2021) A novel locally c-di-GMP-controlled exopolysaccharide synthase required for N4 phage infection of E. coli. bioRxiv preprint, version posted October 1. doi: https://doi.org/10.1101/2021.10.01.462733.
Oren, N., Timm, S., Frank, M., Mantovani, O., Murik, O., and M. Hagemann (2021) Red/far-red light signals regulate the activity of the carbon-concentrating mechanism in cyanobacteria. Sci. Adv. Aug 18;7(34):eabg0435. doi: 10.1126/sciadv.abg0435. Print 2021 Aug.
Rick, T., Kreiling, V.,Höing, A., Fiedler, S., Glatter, T., Steinchen, W., Hochberg, G., Bähre, H., Seifert, R., Bange, G., Knauer, S.K., Peter L. Graumann, P.L., and K.M, Thormann (2021) A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by direct interaction with a polar landmark protein. bioRxiv preprint, version posted August 12.
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Pecina, A., Schwan, M., Blagotinsek, V., Rick, T., Klüber, P., Leonhard, T., Bange, G., and Thormann, K.M. (2021) The stand-alone PilZ-domain protein MotL specifically regulates the activity of the secondary lateral flagellar system in Shewanella putrefaciens. Front. Microbiol. Jun 1;12:668892. doi: 10.3389/fmicb.2021.668892. eCollection 2021. » PubMed
Kuzmich†, S., Skotnicka†, D., Szadkowski, D., Klos, P., Pérez-Burgos, M., Schander, E., Schumacher, D., and L., Søgaard-Andersen (2021) Three PilZ domain proteins, PlpA, PixA and PixB, have distinct functions in regulation of motility and development in Myxococcus xanthus. J Bacteriol. Apr 19;JB.00126-21. doi: 10.1128/JB.00126-21. Online ahead of print.
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Hengge, R. (2021) High-Specificity Local and Global c-di-GMP Signaling. Trends Microbiol.
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Krüger, L., Herzberg, C., Wicke, D., Bähre, H., Heidemann, J.L., Dickmanns, A., Schmitt, K., Ficner, R., and J., Stülke (2021) A meet-up of two second messengers: the c-di-AMP receptor DarB controls (p)ppGpp synthesis in Bacillus subtilis. Nat Commun. Feb 22;12(1):1210.
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Krüger, L., Herzberg, C., Rath, H,, Pedreira, T., Ischebeck, T., Poehlein, A., Gundlach, J., Daniel, R., Völker, U., Mäder, U., and J. Stülke (2021) Essentiality of c-di-AMP in Bacillus subtilis: Bypassing mutations converge in potassium and glutamate homeostasis. PLoS Genet. Jan 22;17(1):e1009092. doi: 10.1371/journal.pgen.1009092. Online ahead of print.
Binas†, O., de Jesus†, V., Landgraf†, T., Völklein†, A. E., Martins, J., Hymon, D., Kaur Bains, J., Berg, H., Biedenbänder, T., Fürtig, B., Lakshmi Gande, S., Niesteruk, A., Oxenfarth, A., Shahin Qureshi, N., Schamber, T., Schnieders, R., Tröster, A., Wacker, A., Wirmer-Bartoschek, J., Wirtz Martin, M. A., Stirnal, E., Azzaoui, K., Richter, C., Sreeramulu, S., José Blommers, M. J., and Schwalbe, H. (2021). 19 F NMR-Based Fragment Screening for 14 Different Biologically Active RNAs and 10 DNA and Protein Counter-Screens. Chembiochem. Jan 15;22(2):423-433. https://doi.org/10.1002/cbic.202000476 († these authors contributed equally)
Steinchen*, W., Ahmad, S., Valentini, M., Eilers, K., Majkini, M., Altegoer, F., Lechner, M,, Filloux, A,, Whitney, J.C., G. Bange* (2021) Dual role of a (p)ppGpp- and (p)ppApp-degrading enzyme in biofilm formation and interbacterial antagonism. Mol Microbiol. Jan 15.
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Hengge, R. (2021) Crosstalking second messengers. Nat Microbiol. Jan;6(1):9-10.
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Latoscha†*, A., Drexler†*, D. J., Witte, G., and Tschowri, N. (2021) Assessment of Diadenylate Cyclase and c-di-AMP-phosphodiesterase Activities Using Thin-layer and Ion Exchange Chromatography. Bio Protoc., Jan 5;11(1):e3870. https://doi.org/10.21769/BioProtoc.3870 († these authors contributed equally), (* corresponding authors)
2020
Horvatek, P., Salzer, A., Hanna, A.M.F., Gratani, F.L., Keinhörster, D., Korn, N., Borisova, M., Mayer, C., Rejman, D., Mäder, U., and C. Wolz (2020) Inducible expression of (pp)pGpp synthetases in Staphylococcus aureus is associated with activation of stress response genes. PLoS Genet. Dec 30;16(12):e1009282. doi: 10.1371/journal.pgen.1009282. Online ahead of print.
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Oeser, S., Wallner, T., Schuergers, N., Bučinská, L., Sivabalasarma, S., Bähre, H., Albers, S. V., & Wilde, A. (2021) Minor pilins are involved in motility and natural competence in the cyanobacterium Synechocystis sp. PCC 6803. Mol. Microbiol., 116(3), 743–765. https://doi.org/10.1111/mmi.14768
Fritsch, V.N., Loi, V.V., Busche, T., Tung, Q.N., Lill, R., Horvatek, P., Wolz, C., Kalinowski, J., and H. Antelmann (2020) The alarmone (p)ppGpp confers tolerance to oxidative stress during the stationary phase by maintenance of redox and iron homeostasis in Staphylococcus aureus. Free Radic Biol Med. Nov 1;S0891-5849(20)31596-3.
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Salzer, A., Keinhörster, D., Kästle, C., Kästle, B., and C. Wolz (2020) Small alarmone synthetases RelP and RelQ of Staphylococcus aureus are involved in biofilm formation and maintenance under cell wall stress conditions. Front Microbiol. Sep 18;11:575882.
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Pausch, P., Abdelshahid, M., Steinchen, W., Schäfer, H., Gratani, F.L., Freibert, S-A., Wolz, C., Turgay*, K., Wilson*, D.N., and G. Bange* (2020) Structural basis for regulation of the opposing (p)ppGpp synthetase and hydrolase within the stringent response orchestrator Rel. Cell Rep. Sep 15;32(11):108157. doi: 10.1016/j.celrep.2020.108157. (* corresponding authors)
Steinchen, W., Zegarra, V., and G. Bange (2020) (p)ppGpp: Magic modulators of bacterial physiology and metabolism. Front Microbiol. Sep 7;11:2072. doi: 10.3389/fmicb.2020.02072.
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Physiology of guanosine-based second messenger signaling in Bacillus subtilis. Biol Chem. Sep 1;/j/bchm.just-accepted/hsz-2020-0241/hsz-2020-0241.xml. doi: 10.1515/hsz-2020-0241. Online ahead of print.
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, L., , C., , D., , H., , J.L, , A., , K., , A rendezvous of two second messengers: The c-di-AMP receptor protein DarB controls (p)ppGpp synthesis in Bacillus subtilis. bioRxiv preprint, version posted August 27 doi: https://doi.org/10.1101/2020.05.20.106443.
Haist, J., Neumann, S.A., Al-Bassam, M.M., Lindenberg, S., Elliot, M.A., and N. Tschowri (2020) Specialized and shared functions of diguanylate cyclases and phosphodiesterases in Streptomyces development. Mol Microbiol. Aug 14. Online ahead of print.
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Binas, O., Schamber, T., and Schwalbe, H. (2020). The conformational landscape of transcription intermediates involved in the regulation of the ZMP-sensing riboswitch from Thermosinus carboxydivorans. Nucleic Acids Res., Jul 9;48(12):6970-6979. https://doi.org/10.1093/nar/gkaa427
Richter, A.M., Possling, A., Malysheva, N., Yousef, K.P., Herbst, S., von Kleist, M., and R. Hengge (2020) Local c-di-GMP signaling in the control of synthesis of the E. Coli biofilm exopolysaccharide pEtN-cellulose. J M Biol. Jul 24;432(16):4576-4595. doi: 10.1016/j.jmb.2020.06.006. Epub 2020 Jun 11.
Cyclic di-AMP signaling in bacteria. Annu Rev Microbiol. 2020 Jun 30. doi: 10.1146/annurev-micro-020518-115943. Online ahead of print.
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Wallner, T., Pedroza, L., Voigt, K., Kaever, V., and A. Wilde (2020) The cyanobacterial phytochrome 2 regulates the expression of motility-related genes through the second messenger cyclic di-GMP. Photochem Photobiol Sci. May 1;19(5):631-643. doi: 10.1039/c9pp00489k. Epub 2020 Apr 7.
Horvatek, P., Hanna, A.M.F., Gratani, F.L., Keinhörster, D., Korn, N., Borisova, M., Mayer, C., Rejman, D., Mäder, U., and C. Wolz (2020) Inducible expression of (pp)pGpp synthetases in Staphylococcus aureus is associated with activation of stress response genes. bioRxiv preprint, version posted April 25. doi: https://doi.org/10.1101/2020.04.25.059725.
Skotnicka, D., Steinchen, W., Szadkowski, D., Cadby, I.T., Lovering, A.L., Bange, G., and L. Søgaard-Andersen (2020) CdbA is a DNA-binding protein and c-di-GMP receptor important for nucleoid organization and segregation in Myxococcus xanthus. Nat Commun.
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Gibhardt, J., Heidemann, J.L, Bremenkamp, R., Rosenberg, J., Seifert, R., Kaever, V., Ficner, R., and F.M. Commichau (2020) An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes. Environ Microbiol. Apr 6. doi: 10.1111/1462-2920.15008. Online ahead of print.
Hengge, R. (2020) Linking bacterial growth, survival, and multicellularity – small signaling molecules as triggers and drivers. Curr Opin Microbiol. Mar 31;55:57-66.
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Latoscha†, A., Drexler†, D.J., Al-Bassam, M.M., Bandera, A.M., Kaever, V., Findlay, K.C., Witte*, G., and N. Tschowri* (2020) c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria. Proc Natl Acad Sci U S A.
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Enomoto, G., Kamiya, A., Okuda, Y., Narikawa, R. and M. Ikeuchi (2020) Tlr0485 is a cAMP-activated c-di-GMP phosphodiesterase in a cyanobacterium Thermosynechococcus.
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Enomoto, G., and M. Ikeuchi (2020) Blue-/Green-Light-Responsive Cyanobacteriochromes Are Cell Shade Sensors in Red-Light Replete Niches. iScience. Mar 27;23(3):100936.
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Schäfer, H., Beckert, B., Frese, C.K., Steinchen, W., Nuss, A., Beckstette, M., Hantke, I., Driller, K., Sudzinová, P., Krásný, L., Kaever, V., Dersch, P., Bange*, G., Wilson*, D.N. and K. Turgay* The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis. PLoS Genet. Mar 16;16(3):e1008275. doi: 10.1371/journal.pgen.1008275. eCollection 2020 Mar. (* corresponding authors)
Enomoto G., Wilde A., and M. Ikeuchi (2020) Light-Regulated Nucleotide Second Messenger Signaling in Cyanobacteria. In: Chou SH., Guiliani N., Lee V., Römling U. (eds) Microbial Cyclic Di-Nucleotide Signaling. Springer, Cham pp 311-327. First Online:
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Pérez-Burgos, M., and L. Søgaard-Andersen (2020) Regulation by c-di-GMP in Myxococcus xanthus. In: Chou SH., Guiliani N., Lee V., Römling U. (eds) Microbial Cyclic Di-Nucleotide Signaling. Springer, Cham pp. 293-309. First Online:
https://doi.org/10.1007/978-3-030-33308-9_18
Tascón, I., Sousa, J.S., Corey, R.A., Mills, D.J., Griwatz, D., Aumüller, N., Mikusevic, V., Stansfeld, P.J., Vonck, J., and I. Hänelt (2020) Structural basis of proton-coupled potassium transport in the KUP family. Nat Commun. Jan 31;11(1):626. doi: 10.1038/s41467-020-14441-7.
2019
Shimokawa-Chiba†, N., Müller†, C., Fujiwara, K., Beckert, B., Ito, K., Wilson*, D.N., and S. Chiba* (2019) Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis. Nat Commun. Nov 27;10(1):5397. doi: 10.1038/s41467-019-13408-7. († equal contribution, * corresponding authors)
Latoscha,A., Wörmann, M.E., and N. Tschowri (2019) Nucleotide second messengers in Streptomyces. Microbiology. Nov;165(11):1153-1165. doi: 10.1099/mic.0.000846.
Gibhardt, J., Hoffmann, G., Turdiev, A., Wang, M., Lee, V.T., and F. M. Commichau (2019)
c-di-AMP assists osmoadaptation by regulating the Listeria monocytogenes potassium transporters KimA and KtrCD. J Biol Chem. Nov 1;294(44):16020-16033. doi: 10.1074/jbc.RA119.010046. Epub 2019 Sep 9.
Erdmann, J., Thöming, J.G., Pohl, S., Pich, A., Lenz, C., and S. Häussler (2019) The core proteome of biofilm-grown clinical Pseudomonas aeruginosa isolates. Cells. Sep 23;8(10). pii: E1129. doi: 10.3390/cells8101129.
Braun, F., Thomalla, L., van der Does, C., Quax, T.E.F., Allers, T., Kaever, V., and S.V. Albers (2019) Cyclic nucleotides in archaea: Cyclic di-AMP in the archaeon Haloferax volcanii
and its putative role. Microbiologyopen. Sep;8(9):e00829. doi: 10.1002/mbo3.829. Epub 2019 Mar 18.
Conradi, F.D., Zhou, R.Q., Oeser, S., Schuergers, N., Wilde, A., and C.W. Mullineaux (2019) Factors controlling floc formation and structure in the cyanobacterium Synechocystis sp. PCC 6803. J Bacteriol. Sep 6;201(19). pii: e00344-19. doi: 10.1128/JB.00344-19. Print 2019 Oct 1.
McLean, T.C., Lo, R., Tschowri, N., Hoskisson, P.A., Al Bassam, M.M., Hutchings, M.I., and N.F. Som (2019) Sensing and responding to diverse extracellular signals: an updated analysis of the sensor kinases and response regulators of Streptomyces species. Microbiology. Sep;165(9):929-952. doi: 10.1099/mic.0.000817.
Schäfer, H., and K. Turgay (2019) Spx, a versatile regulator of the Bacillus subtilis stress response. Curr Genet. Aug;65(4):871-876. doi: 10.1007/s00294-019-00950-6. Epub 2019 Mar 4.
Kordes, A., Grahl, N., Koska, M., Preusse, M., Arce-Rodriguez, A., Abraham, W.R., Kaever, V., and S. Häussler (2019) Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host. ISME J. Aug;13(8):2018-2030. doi: 10.1038/s41396-019-0412-1. Epub 2019 Apr 5.
Heidemann, J.L., Neumann, P., Dickmanns, A., and R. Ficner (2019) Crystal structures of the c-di-AMP synthesizing enzyme CdaA. J Biol Chem. Jul 5;294(27):10463-10470. doi: 10.1074/jbc.RA119.009246. Epub 2019 May 22.
Serra, D.O., and R. Hengge (2019) Cellulose in Bacterial Biofilms. In: Cohen E., Merzendorfer H. (eds) Extracellular Sugar-Based Biopolymers Matrices. Biologically-Inspired Systems, vol 12.
pp 355-392. Springer, Cham. First Online:
https://link.sprinhttps://link.springer.com/chapter/10.1007/978-3-030-12919-4_8
Hengge, R. (2019) Targeting Bacterial Biofilms by the Green Tea Polyphenol EGCG. Molecules. Jun 29;24(13). pii: E2403. doi: 10.3390/molecules24132403.
Grobe, S., Doberenz, S., Ferreira, K., Krueger, J., Brönstrup, M., Kaever, V., and S. Häussler (2019) Identification and Quantification of (t)RNA Modifications in Pseudomonas aeruginosa by Liquid Chromatography-Tandem Mass Spectrometry. Chembiochem. Jun 3;20(11):1430-1437. doi: 10.1002/cbic.201800741. Epub 2019 Apr 5.
Bense, S., Bruchmann, S., Steffen, A., Stradal, T.E.B., Häussler*, S., and J. Düvel* (2019) Spatiotemporal control of FlgZ activity impacts Pseudomonas aeruginosa flagellar motility. Mol Microbiol. Jun;111(6):1544-1557. doi: 10.1111/mmi.14236. Epub 2019 Mar 29.
(* corresponding authors)
Gundlach, J., Krüger, L., Herzberg, C., Turdiev, A., Poehlein, A., Tascón, I. , Weiß, M. , Hertel, D., Daniel, R, Hänelt, I., Lee, V.T., and J. Stülke (2019) Sustained sensing in potassium homeostasis: Cyclic di-AMP controls potassium uptake by KimA at the levels of expression and activity. J Biol Chem. Jun 14;294(24):9605-9614. doi: 10.1074/jbc.RA119.008774. Epub 2019 May 6.
Pfiffer, V., Sarenko, O., Possling, A., and R. Hengge (2019) Genetic dissection of Escherichia coli’s master diguanylate cyclase DgcE: Role of the N-terminal MASE1 domain and direct signal input from a GTPase partner system. PLoS Genet. Apr 25;15(4):e1008059.
doi: 10.1371/journal.pgen.1008059. eCollection 2019 Apr.
, I.M., , J., , A., , E., , F.M., , V.T., , C., and The KupA and KupB proteins of Lactococcus lactis IL1403 are novel c-di-AMP receptor proteins responsible for potassium uptake. J. Bacteriol. Apr 24;201(10). pii: e00028-19. doi: 10.1128/JB.00028-19. Print 2019 May 15. (* corresponding authors)
Onwards and [K+]upwards: a new potassium importer under the spell of cyclic-di-AMP
Serra, D.O., and R. Hengge (2019) A c-di-GMP-Based Switch Controls Local Heterogeneity of Extracellular Matrix Synthesis which Is Crucial for Integrity and Morphogenesis of Escherichia coli Macrocolony Biofilms. J Mol Biol. Apr 4. pii: S0022-2836(19)30177-9.
doi: 10.1016/j.jmb.2019.04.001. [Epub ahead of print]
Rossmann†, F.M., Rick†, T., Mrusek, D., Sprankel, L., Dörrich, A.K., Leonhard, T., Bubendorfer, S., Kaever, V., Bange, G., and K.M. Thormann (2019) The GGDEF domain of the phosphodiesterase PdeB in Shewanella putrefaciens mediates recruitment by the polar landmark protein HubP. J. Bacteriol. Mar 13;201(7). pii: e00534-18. doi: 10.1128/JB.00534-18. Print 2019 Apr 1. († equal contribution) Articles of Significant Interest Selected by the Editors: Exploring How a Phosphodiesterase Is Recruited to the Cell Pole in Shewanella putrefaciens
https://jb.asm.org/content/201/7/e00100-19
Recent Advances and Current Trends in Nucleotide Second Messenger Signaling in Bacteria.
J Mol Biol. Mar 1;431(5):908-927. doi:10.1016/j.jmb.2019.01.014. Epub 2019 Jan 19.
Schäfer, H., Heinz, A., Sudzinová, P., Voß, M., Hantke, I., Krásný, L., and K. Turgay (2019)
Spx, the central regulator of the heat- and oxidative stress response in B. subtilis, can repress transcription of translation-related genes. Mol Microbiol. Feb;111(2):514-533. doi: 10.1111/mmi.14171. Epub 2018 Dec 11.
Hantke, I., Schäfer, H., Janczikowski, A., and K. Turgay (2019) YocM a small heat shock protein can protect Bacillus subtilis cells during salt stress. Mol Microbiol. Feb;111(2):423-440. doi: 10.1111/mmi.14164. Epub 2018 Dec 4.
Thomanek, N., Arends, J., Lindemann, C., Barkovits, K., Meyer, H.E., Marcus, K., and N. Narberhaus (2019) Intricate crosstalk between lipopolysaccharide, phospholipid and fatty acid metabolism in Escherichia coli modulates proteolysis of LpxC. Front. Microbiol. Jan 14;9:3285. doi: 10.3389/fmicb.2018.03285. eCollection 2018.
2018
Pausch, P., Steinchen, W., Wieland, M., Klaus, T., Freibert, S.A., Altegoer, F., Wilson, D.N., and G. Bange (2018) Structural basis for (p)ppGpp-mediated inhibition of the GTPase RbgA.
J Biol Chem. Dec 21;293(51):19699-19709. doi: 10.1074/jbc.RA118.003070. Epub 2018 Oct 26.
, F.M., , J.L., Making and breaking of an essential poison: the cyclases and phosphodiesterases that produce and degrade the essential second messenger cyclic di-AMP in bacteria. J Bacteriol. Dec 7;201(1). pii: e00462-18. doi: 10.1128/JB.00462-18. Print 2019 Jan 1.
Erdmann, J., Preusse, M., Khaledi, A., Pich, A., and S. Häussler (2018) Environment-driven changes of mRNA and protein levels in Pseudomonas aeruginosa. Environ Microbiol. Nov;20(11):3952-3963. doi: 10.1111/1462-2920.14419. Epub 2018 Oct 22.
Bedrunka, P., Olbrisch, F., Rüger, M., Zehner, S., and N. Frankenberg-Dinkel (2018) Nitric oxide controls c-di-GMP turnover in Dinoroseobacter shibae. Microbiology. Nov;164(11):1405-1415. doi: 10.1099/mic.0.000714. Epub 2018 Sep 17.
Al-Bassam, Haist†, J., Neumann†, S.A., Lindenberg, S., and N. Tschowri (2018)
Expression patterns, genomic conservation and input into developmental regulation of the GGDEF/EAL/HD-GYP domain proteins in Streptomyces. Front. Microbiol., Oct 23;9:2524.
doi: 10.3389/fmicb.2018.02524. eCollection 2018. († equal contribution)
Beckert†, B., Turk†, M., Czech, A., Berninghausen, O., Beckmann, R., Ignatova, Z., Plitzko*, J.M., and D.N. Wilson* (2018) Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1. Nat Microbiol. Oct;3(10):1115-1121. doi: 10.1038/s41564-018-0237-0. Epub 2018 Sep 3. († equal contribution, * corresponding authors) » PubMed
Journal cover October 2018
Highlighted in:
1. Informationsdienst Wissenschaft: Forschungsteam der Universität Hamburg identifiziert Aufbau von 100S-Ribosomen » Read more
2. FOCUS Online: Universität Hamburg – Meldung vom 04.09.2018 » Read more
3. LABO Online: Aufbau von 100S-Ribosomen identifiziert » Read more
4. LaborPraxis: Beim Rendezvous der Ribosomen zugeschaut » Read more
Keller, H., Weickhmann, A.K., Bock, T., and J. Wohnert (2018) Adenine protonation enables cyclic-di-GMP binding to cyclic-GAMP sensing riboswitches. RNA. Oct;24(10):1390-1402. doi: 10.1261/rna.067470.118. Epub 2018 Jul 13. » PubMed
Quintana, I., Espariz, M., Villar, S., Gonzalez, F. B., Pacini, F., Cabrera, G., Bontempi, I., Procheto, E., Stülke, J., Perez, A. R., Marcipar, I., Blancato, V., and C. Magni (2018) Genetic engineering of Lactococcus lactis co-producing antigen and the mucosal adjuvant 3′ 5′- cyclic di adenosine monophosphate (c-di-AMP) as a design strategy to develop a mucosal vaccine prototype. Front. Microbiol. Sep 4;9:2100. doi: 10.3389/fmicb.2018.02100. eCollection 2018.
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Klauck, G., Serra, D.O., Possling, A., and R. Hengge (2018) Spatial organization of different sigma factor activities and c-di-GMP signalling within the three-dimensional landscape of a bacterial biofilm. Open Biol. Aug 8(8). pii: 180066. doi: 10.1098/rsob.180066. » PubMed
Gratani, F.L., Horvatek, P., Geiger, T., Borisova, M., Mayer, C., Grin, I., Wagner, S., Steinchen, W., Bange, G., Velic, A., Maček, B., and C. Wolz (2018)
Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus. PLoS Genet. Jul 9;14(7):e1007514. doi: 10.1371/journal.pgen.1007514. eCollection 2018 Jul. » PubMed
Commichau, F.M., and J. Stülke (2018) Coping with an essential poison: a genetic suppressor analysis corroborates a key function of c-di-AMP in controlling potassium ion homeostasis in Gram-positive bacteria. J Bacteriol. May 24;200(12). pii: e00166-18. doi: 10.1128/JB.00166-18. Print 2018 Jun 15. » PubMed
Herbst, S., Lorkowski, M., Sarenko, O., Nguyen, T.K.L., Jaenicke, T., and R. Hengge (2018)
Transmembrane redox control and proteolysis of PdeC, a novel type of c-di-GMP
phosphodiesterase. EMBO J. Apr 13;37(8). pii: e97825. doi: 10.15252/embj.201797825. Epub 2018 Mar 7. » PubMed
Commichau, F.M., Gibhardt, J., Halbedel, S., Gundlach, J., and J. Stülke (2018) A Delicate Connection: c-di-AMP Affects Cell Integrity by Controlling Osmolyte Transport. Trends Microbiol. Mar;26(3):175-185. doi: 10.1016/j.tim.2017.09.003. Epub 2017 Sep 28.
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Journal cover March 2018
Highlighted by Faculty of 1000:
Waters, C. : In F1000Prime, 09 October 2017. doi: 10.3410/f.731603148.793537473.
Gundlach, J., Commichau, F.M., and J. Stülke (2018) Of ions and messengers: an intricate link between potassium, glutamate, and cyclic di-AMP. Curr Genet. Feb;64(1):191-195. doi: 10.1007/s00294-017-0734-3. Epub 2017 Aug 20. » PubMed
Thongsomboon, W., Serra, D.O., Possling, A., Hadjineophytou, C., Hengge*, R., and
L. Cegelski* (2018) Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose. Science. Jan 19;359(6373):334-338. doi: 10.1126/science.aao4096. (*corresponding authors) » PubMed
Highlighted in:
1. Perspectives Section of the Science Journal: Galperin, M. and Shalaeva, D.: A bacterial coat that is not pure cotton. Science 2018 Jan 19;359(6373):276-277. doi: 10.1126/science.aar5253. » Read more
2. Science News: The secret to icky, sticky bacterial biofilms lies in the microbes’ cellulose. » Read more
3. Nature highlight: How bacteria make their fortresses. » Read more
4. Chemical & Engineering News: Bacteria make modified cellulose. » Read more
5. Phys.org News: Bacterial biofilm cellulose found to differ from plant cellulose. » Read more
6. Nature Microbiology: Do Gram-negatives produce cellulose or not? » Read more
7. F1000Prime by G. Nester, 12 February 2018. doi: 10.3410/f.732501572.793542371.
8. F1000Prime by C. Whitfield, 16 February 2018. doi: 10.3410/f.732501572.793542459.
2017
Drexler, D.J., Müller, M., Rojas-Cordova, C.A., Bandera, A.M., and G. Witte (2017) Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima. Structure. Oct 24. pii: S0969-2126(17)30329-5. doi: 10.1016/j.str.2017.10.001. Epub 2017 Oct 26. » PubMed
Sarenko, O., Klauck, G., Wilke, F.M., Pfiffer, V., Richter,A.M., Herbst, S., Kaever, V., and R. Hengge (2017) More than enzymes that make and break c-di-GMP – Local signaling in the interactome of GGDEF/EAL domain proteins of Escherichia coli. mBio. Oct 10;8(5). pii: e01639-17. doi: 10.1128/mBio.01639-17. » PubMed
Highlighted by Faculty of 1000:
1. Sondermann, H. : In F1000Prime, 19 October 2017. doi: 10.3410/f.731966577.793537737;
2. Galperin, M. : In F1000Prime, 20 October 2017. doi:10.3410/f. 731966577.793537754.
Bähre, H., and V. Kaever (2017) Identification and Quantification of Cyclic Di-Guanosine
Monophosphate and Its LinearMetabolites by Reversed-Phase LC-MS/MS. In: Sauer K. (eds)
c-di-GMP Signaling. Methods in Molecular Biology, vol 1657. Humana Press, New York, NY, 1657:45-58. doi: 10.1007/978-1-4939-7240-1_5. » PubMed
Serra, D.O., and R. Hengge (2017) Experimental detection and visualization of the extracellular matrix in macrocolony biofilms. In: Sauer K. (eds) c-di-GMP Signaling. Methods in Molecular Biology, vol 1657. Humana Press, New York, N.Y., 1657:133-145. doi: 10.1007/978-1-4939-7240-1_11. » PubMed
Angerer, V., Essen, L.O., and A. Wilde (2017) Analysis of c-di-GMP levels synthesized by a photoreceptor protein in response to different light qualities using an in vitro enzymatic assay. In: Sauer K. (eds) c-di-GMP Signaling. Methods in Molecular Biology, vol 1657. Humana Press, New York, N.Y., 1657:187-204. doi: 10.1007/978-1-4939-7240-1_15. » PubMed
Kampf, J., Gundlach, J., Herzberg, C., Treffon, K., and J. Stülke (2017) Identification of c-di-AMP-binding proteins using magnetic beads. In: Sauer K. (eds) c-di-GMP Signaling. Methods in Molecular Biology, vol 1657. Humana Press, New York, N.Y., 1657:347-359. doi: 10.1007/978-1-4939-7240-1_27. » PubMed
Beckert†, B., Abdelshahid†, M., Schäfer, H., Steinchen, W., Arenz, S., Berninghausen, O., Beckmann, R., Bange*, G., Turgay*, K., and D.N. Wilson* (2017) Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization. EMBO J. Jul 14;36(14):2061-2072. doi: 10.15252/embj.201696189. Epub 2017 May 3. († equal contribution, * corresponding authors) » PubMed
Highlighted in the News & Views section of the EMBO Journal:
Gonzalez, R.L. Jr. : Survivor: Ribosome Edition. EMBO J. 2017 Jul 14;36(14):1996-1998. doi: 10.15252/embj.201797518. » PubMed
Blötz, C., Treffon, K., Kaever, V., Schwede, F., Hammer, E., and J. Stülke (2017) Identification of the components involved in cyclic di-AMP signaling in Mycoplasma pneumoniae. Front. Microbiol. Jul 13;8:1328. doi: 10.3389/fmicb.2017.01328. eCollection 2017. » PubMed
Gundlach, J., Herzberg, C., Hertel, D., Thürmer, A., Daniel, R., Link, H., and J. Stülke (2017) Adaptation of Bacillus subtilis to life at extreme potassium limitation. mBio. Jul 5;8(4). pii: e00861-17. doi: 10.1128/mBio.00861-17. » PubMed
Highlighted by Faculty of 1000:
Clausen, T. and Suskiewicz, M. : In F1000Prime, 06 October 2017. doi: 10.3410/f.727781851.793537409.
Angerer, V., Schwenk, P., Wallner, T., Kaever, V., Hiltbrunner, A., and A. Wilde (2017) The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2. Microbiology. Jun;163(6):920-930. doi: 10.1099/mic.0.000475. Epub 2017 Jun 21. » PubMed
Schumacher, MA., Zeng, W., Findlay, K.C., Buttner, M.J., Brennan, R.G., and N. Tschowri (2017) The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. Nucleic Acids Res. Jun 20;45(11):6923-6933. doi: 10.1093/nar/gkx287. » PubMed
Schuergers, N., Mullineaux, C.W., and Wilde, A. (2017) Cyanobacteria in motion. Curr. Opin. Plant Biol. Jun;37:109-115. doi: 10.1016/j.pbi.2017.03.018. Epub 2017 May 1. » PubMed
Gundlach, J., Herzberg, C., Kaever, V., Gunka, K., Hoffmann, T., Weiß, M., Gibhardt, J., Thürmer, A., Hertel, D., Daniel, R., Bremer, E., Commichau, F.M., and J. Stülke (2017) Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis. Sci. Signal. Apr 18;10(475). pii: eaal3011. doi: 10.1126/scisignal.aal3011.
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2016
Krol, E., Klaner, C., Gnau, P., Kaever, V., Essen, LO., and A. Becker (2016) Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti. Microbiology. Oct;162(10):1840-1856. doi: 10.1099/mic.0.000356. Epub 2016 Aug 16. » PubMed
Arenz, S., Abdelshahid, M., Sohmen, D., Payoe, R., Starosta, A.L., Berninghausen, O., Hauryliuk, V., Beckmann, R., and D.N. Wilson (2016) The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis. Nucleic Acids Res. Jul 27;44(13):6471-81. doi: 10.1093/nar/gkw470. Epub 2016 May 25. » PubMed