Research Project

Dynamic basis of the molecular mechanism of nucleotide secondary messenger-sensing riboswitches by NMR spectroscopy

Riboswitches are cis-acting regulatory RNA elements involved into the modulation of translational or transcriptional efficiency, binding small-molecule ligands.

In this project second-messenger binding bacterial riboswitches are investigated by NMR methods. NMR offers unmatched precision for such scientific studies, enabling investigations in atomic resolution. Applied methods range from the characterization of the conformational space of riboswitches over structural profiling to kinetic investigation involving a multitude of NMR methods such as proton 1D, 2D-NOESY, HSQC and application of modern isotope labeling methods.

Principle Investigators

Prof. Dr. Harald Schwalbe
» schwalbe@nmr.uni-frankfurt.de

Prof. Dr. Jens Wöhnert
» Woehnert@bio.uni-frankfurt.de

Co-workers

Tom Landgraf (Schwalbe Group)
» Landgraf@nmr.uni-frankfurt.de