Research Project

Function of c-di-AMP in archaea

Very little knowledge is available about the occurrence and function of cyclic nucleotides as second messengers in Archaea. We have demonstrated that the extremely halophilic archaeon Haloferax volcanii produces c-di-AMP and now want to understand its function in this organism. First experiments hint at a function in osmoregulation as an H. volcanii strain producing less c-di-AMP swells up under hyposalt conditions (Braun et al., 2019). Moreover, the euryarchaeal diadenylate cyclase exhibits an additional N-terminal domain otherwise found in pyruvate kinases. We want to study the influence of this domain on the function of the diadenylate cyclase.

Principle Investigators

Prof. Dr. Sonja Verena Albers