Research Project

Novel biological functions of ppGpp in Escherichia coli

(p)ppGpp is a widespread second messenger best known as alarmone that alerts the cell to starvation conditions and leads to major re-arrangements in bacterial physiology. However, the signaling molecule affects numerous other pathways, among them the growth-rate controlled proteolysis of LpxC, an essential enzyme for lipopolysaccharide biosynthesis.

The project aims at the identification of ppGpp-binding proteins with a focus on enzymes involved in LPS and phospholipid biosynthesis. Overall, we expect to provide new insights into the comprehensive role of ppGpp in physiological adaptations of E. coli.

Principle Investigators

Prof. Dr. Franz Narberhaus


Simon Brückner (Funding period 2019-2023)

Fabian Müller (Funding period 2016-2019)